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1. (WO2015134839) P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2015/134839 International Application No.: PCT/US2015/019112
Publication Date: 11.09.2015 International Filing Date: 06.03.2015
IPC:
C07D 401/06 (2006.01) ,C07C 275/06 (2006.01) ,C07C 275/26 (2006.01) ,C07D 401/12 (2006.01) ,C07D 211/58 (2006.01) ,C07D 211/60 (2006.01) ,C07D 211/94 (2006.01) ,C07D 211/96 (2006.01) ,C07D 213/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04
having nitrogen atoms of urea groups bound to acyclic carbon atoms
06
of an acyclic and saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
26
having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Nitrogen atoms
58
attached in position 4
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
92
with a hetero atom directly attached to the ring nitrogen atom
94
Oxygen atom, e.g. piperidine N-oxide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
92
with a hetero atom directly attached to the ring nitrogen atom
96
Sulfur atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
Applicants:
HELSINN HEALTHCARE SA [CH/CH]; Via Pian Scairolo 9 6912 Lugano/Pazzallo, CH
GIULIANO, Claudio [IT/IT]; IT (US)
GARCIA RUBIO, Silvina [US/US]; US (US)
DAINA, Antoine [CH/CH]; CH (US)
GUAINAZZI, Angelo [CH/US]; US (US)
PIETRA, Claudio [IT/IT]; IT (US)
Inventors:
GIULIANO, Claudio; IT
GARCIA RUBIO, Silvina; US
DAINA, Antoine; CH
GUAINAZZI, Angelo; US
PIETRA, Claudio; IT
Agent:
SULLIVAN, Clark, G.; US
Priority Data:
61/949,66407.03.2014US
Title (EN) P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF
(FR) URÉES ASYMÉTRIQUES P-SUBSTITUÉES ET UTILISATIONS MÉDICALES DE CELLES-CI
Abstract:
(EN) Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula (I): or pharmaceutically acceptable salts thereof.
(FR) La présente invention concerne des composés, des compositions et des méthodes pour la prévention et/ou le traitement de maladies qui sont médiées de façon pathophysiologique par le récepteur de ghréline. Les composés ont la Formule générale (I), il peut aussi s'agir des sels pharmaceutiquement acceptables de ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MDa 2016 0100UAa201610056CA2931836AU2015227011CN106170485DOP2016000161
EP3114118JP2017507116MX2016011535MYPI 2016702679PH1/2016/501483VN50375
ID2017/10423TH171895KR1020160130218IN201627033568TN2016000177EA201691796
CR20160458