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1. (WO2015127451) MULTIVALENT/MULTIFUNCTIONAL LIGANDS WITH AGONIST ACTIVITIES AT OPIOID RECEPTORS AND ANTAGONIST ACTIVITIES AT NK1 RECEPTOR FOR RELIEF OF PAIN

Pub. No.:    WO/2015/127451    International Application No.:    PCT/US2015/017324
Publication Date: Fri Aug 28 01:59:59 CEST 2015 International Filing Date: Wed Feb 25 00:59:59 CET 2015
IPC: A61K 38/08
A61P 25/04
A61P 23/00
C07K 7/06
Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventors: HRUBY, Victor, J.
GIRI, Aswini, K.
Title: MULTIVALENT/MULTIFUNCTIONAL LIGANDS WITH AGONIST ACTIVITIES AT OPIOID RECEPTORS AND ANTAGONIST ACTIVITIES AT NK1 RECEPTOR FOR RELIEF OF PAIN
Abstract:
A compound for treatment of pain comprising a single multivalent/multifunctional ligand with agonist activity at opioid receptors and with antagonist activity at NK-1 receptors, joined by a linker. Also disclosed is a pharmaceutical compound comprising the above compound in a pharmaceutically acceptable carrier.