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1. WO2015127409 - SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING

Publication Number WO/2015/127409
Publication Date 27.08.2015
International Application No. PCT/US2015/017173
International Filing Date 23.02.2015
IPC
C07K 1/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
04on carriers
C07K 1/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
10using coupling agents
CPC
C07D 257/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
C07K 1/042
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
04on carriers
042characterised by the nature of the carrier
C07K 1/047
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
04on carriers
047Simultaneous synthesis of different peptide species; Peptide libraries
C07K 1/063
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
06using protecting groups or activating agents
061using protecting groups
063for alpha-amino functions
C07K 1/086
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
06using protecting groups or activating agents
08using activating agents
086containing sulfur
C07K 1/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
10using coupling agents
Applicants
  • VIBRANT HOLDINGS, LLC [US]/[US]
Inventors
  • JAYARAMAN, Vasanth
Agents
  • KRAMMER, Andre, T.
Priority Data
61/942,90321.02.2014US
62/048,68910.09.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING
(FR) PHOTO-ACTIVATION SÉLECTIVE D'ACIDES AMINÉS POUR UN COUPLAGE PEPTIDIQUE EN UNE SEULE ÉTAPE
Abstract
(EN)
Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
(FR)
L'invention porte sur des formulations, des substrats, et des réseaux de synthèse d'acides aminés et de peptides sur des microréseaux. Dans certains modes de réalisation, l'invention porte sur des procédés de préparation et d'utilisation des formulations, des substrats, et des réseaux consistant en un couplage en une seule étape, par exemple, pour la synthèse de peptides dans une orientation C → N. Dans certains modes de réalisation, l'invention porte sur des formulations et des procédés à efficacité élevée de couplage de biomolécules à un substrat.
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