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1. (WO2015127173) THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/127173    International Application No.:    PCT/US2015/016769
Publication Date: 27.08.2015 International Filing Date: 20.02.2015
IPC:
A61P 35/00 (2006.01)
Applicants: AGIOS PHARMACEUTICALS, INC [US/US]; 38 Sidney Street Cambridge, MA 02139 (US)
Inventors: AGRESTA, Samuel, V.; (US).
PRAHL, Malia, Ann; (US)
Agent: MCCARTY, Catherine, M.; (US)
Priority Data:
61/942,172 20.02.2014 US
Title (EN) THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
(FR) COMPOSÉS THÉRAPEUTIQUEMENT ACTIFS ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Disclosed herein are methods of treating advanced solid tumors, such as glioma, intrahepatic cholangiocarcinomas (IHCC), chondrosarcoma, prostate cancer, colon cancer, melanoma, or non-small cell lung cancer (NSCLC), eac characterized by the presence of a mutant allele of IDH1. In one aspect, the present invention provides a method of evaluating a subject, the method comprising: acquiring a value for the level of a compound (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl) amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)- 5-oxopyrrolidine-2-carboxamide (Compound 1), or the level of an alpha hydroxy neoactivity product, e.g., 2HG, e.g., R-2HG (2HG), in the subject.
(FR)L'invention concerne des composés utiles pour traiter un cancer, et des méthodes de traitement du cancer comprenant l'administration, à un sujet en ayant besoin, d'un composé décrit dans l'invention. L'invention concerne des méthodes de traitement de tumeurs solides avancées, telles qu'un gliome, un cholangiocarcinome intrahépatique (IHCC), un chondrosarcome, un cancer de la prostate, un cancer du côlon, un mélanome ou un cancer du poumon non à petites cellules (NSCLC), chacune étant caractérisée par la présence d'un allèle mutant de IDH1. Dans un aspect, la présente invention concerne un procédé d'évaluation d'un sujet, le procédé comprenant : l'acquisition d'une valeur pour le taux d'un composé (S)-N-((S)-1-(2-chlorophényl)-2-((3,3-difluorocyclobutyl) amino)-2-oxoéthyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)- 5-oxopyrrolidine-2-carboxamide (Composé 1), ou pour le taux d'un produit de néoactivité alpha-hydroxy, par exemple 2HG, par exemple, R-2HG (2HG), chez le sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)