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1. (WO2015126808) HBV ASSAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/126808    International Application No.:    PCT/US2015/016110
Publication Date: 27.08.2015 International Filing Date: 17.02.2015
IPC:
A61K 39/29 (2006.01), A61K 31/33 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01), G01N 33/48 (2006.01)
Applicants: BALDWIN, John J. [US/US]; (US)
Inventors: BALDWIN, John J.; (US)
Agent: WOLIN, Harris A.; (US)
Priority Data:
61/966,188 18.02.2014 US
Title (EN) HBV ASSAY
(FR) DOSAGE DU VIRUS DE L'HÉPATITE B
Abstract: front page image
(EN)This invention relates to the discovery that members of the pyrrolotriazinyl class of IGF-1R kinase inhibitors also are inhibitors of the NCTP transporter and block taurocholic acid entry into hepatocytes. An IGF-1R kinase inhibitor such as described in U.S.P. 7,534,792, especially BMS-754807, blocks the NTCP transporter and is therefore useful in preventing Hepatitis B disease, cirrhosis, and hepatic cellular cancer. This preferred compound is (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide.
(FR)La présente invention concerne la découverte selon laquelle des membres de la classe pyrrolotriazinyl des inhibiteurs de la kinase IGF-1R sont également des inhibiteurs du transporteur du NCTP et bloquent l'entrée de l'acide taurocholique dans les hépatocytes. Un inhibiteur de la kinase IGF-1R, tel que celui décrit dans USP 7 534 792, notamment BMS -754807, bloque le transporteur NTCP, et se révèle ainsi utile dans la prévention de l'hépatite B, de la cirrhose, et du cancer des cellules hépatiques. Ce composé préféré est (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4] triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-méthylpyrrolidine-2-carboxamide.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)