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1. (WO2015126729) P97-IDS FUSION PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/126729    International Application No.:    PCT/US2015/015662
Publication Date: 27.08.2015 International Filing Date: 12.02.2015
A61K 38/47 (2006.01), A61K 38/40 (2006.01), A61K 47/48 (2006.01)
Applicants: BIOASIS TECHNOLOGIES, INC. [CA/CA]; 130-10691 Shellbridge Way Richmond, British Columbia V6X 2W8 (CA)
Inventors: VITALIS, Timothy Z.; (CA).
GABATHULER, Reinhard; (CA)
Agent: ROGEL, Mark E.; (US)
Priority Data:
61/941,896 19.02.2014 US
Abstract: front page image
(EN)Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (IDS), and related compositions and methods of use thereof, for instance, to facilitate delivery of IDS across the blood-brain barrier (BBB) and/or improve its tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose Hunter Syndrome (Mucopolysaccharidosis type II; MPS II) and related lysosomal storage disorders, including those having a central nervous system (CNS) component.
(FR)L'invention concerne des protéines de fusion associant p97 (la mélanotransferrine) et l'iduronate-2-sulfatase (IDS), des compositions associées et leurs procédés d'utilisation, par exemple pour faciliter l'administration de l'IDS à travers la barrière hémato-encéphalique (BHE) et/ou améliorer sa pénétration dans le système nerveux central et/ou les tissus périphériques, de façon à traiter et/ou diagnostiquer le syndrome de Hunter ( mucopolysaccharidose de type II; MPS II) et des troubles du stockage lysosomal associés, dont, notamment, ceux présentant une composante relevant du système nerveux central (SNC).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)