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1. (WO2015126713) METHODS AND SYSTEMS FOR PURIFYING AN ACETONITRILE WASTE STREAM AND METHODS FOR SYNTHESIZING OLIGONUCLEOTIDES USING PURIFIED ACETONITRILE WASTE STREAMS

Pub. No.:    WO/2015/126713    International Application No.:    PCT/US2015/015551
Publication Date: Fri Aug 28 01:59:59 CEST 2015 International Filing Date: Fri Feb 13 00:59:59 CET 2015
IPC: C07C 253/34
C07C 255/02
C07C 255/01
Applicants: HONEYWELL INTERNATIONAL INC.
Inventors: GAJDA, Gregory J.
RILEY, Mark G.
MOHAN, Venkatraman
LORENZ, Sandra M.
COHEN, Alan P.
Title: METHODS AND SYSTEMS FOR PURIFYING AN ACETONITRILE WASTE STREAM AND METHODS FOR SYNTHESIZING OLIGONUCLEOTIDES USING PURIFIED ACETONITRILE WASTE STREAMS
Abstract:
Methods and systems for purifying an acetonitrile waste stream and methods for synthesizing an oligonucleotide using a purified acetonitrile waste stream are provided. An exemplary method for purifying an acetonitrile waste stream includes providing an acetonitrile waste stream and fractionating the acetonitrile waste stream to produce a single overhead fraction. The method includes condensing the single overhead fraction to produce a condensed single overhead fraction and contacting the condensed single overhead fraction with an adsorbent to produce an acetonitrile stream that comprises an amount of at least one impurity that is reduced relative to the acetonitrile waste stream.