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1. (WO2015126694) METHOD AND APPARATUS FOR SUPRACHOROIDAL ADMINISTRATION OF THERAPEUTIC AGENT

Pub. No.:    WO/2015/126694    International Application No.:    PCT/US2015/015362
Publication Date: Fri Aug 28 01:59:59 CEST 2015 International Filing Date: Thu Feb 12 00:59:59 CET 2015
IPC: A61F 9/00
Applicants: ETHICON ENDO-SURGERY, LLC.
JANSSEN RESEARCH & DEVELOPMENT, LLC
Inventors: OBERKIRCHER, Brendan J.
PRICE, Daniel W.
KEANE, Michael F.
SOKHANVAR, Saeed
YASEVAC, Daniel J.
BRUEHWILER, Michel G.
SOFFER, Leah R.
KHAN, Isaac J.
KO, Benjamin L.
RIEMANN, Christopher D.
GRUBBS, Nathan D.
Title: METHOD AND APPARATUS FOR SUPRACHOROIDAL ADMINISTRATION OF THERAPEUTIC AGENT
Abstract:
An apparatus (10) for delivering therapeutic agent to an eye comprises a body (40), a cannula (20), a hollow needle (30), and an actuation assembly (60). The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.