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1. (WO2015126528) BIOPHYSICALLY SORTED OSTEOPROGENITORS FROM CULTURE EXPANDED BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS (MSCS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/126528    International Application No.:    PCT/US2015/000029
Publication Date: 27.08.2015 International Filing Date: 18.02.2015
IPC:
C12N 5/0775 (2010.01), C12N 5/074 (2010.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139 (US).
NATIONAL UNIVERSITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road Singapore 119077 (SG)
Inventors: POON, Zhiyong; (SG).
LEE, Wong, Cheng; (SG).
VAN VLIET, Krystyn, J.; (US)
Agent: CARROLL, Alice, O.; (US)
Priority Data:
61/941,081 18.02.2014 US
Title (EN) BIOPHYSICALLY SORTED OSTEOPROGENITORS FROM CULTURE EXPANDED BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS (MSCS)
(FR) OSTÉOPROGÉNITEURS BIOPHYSIQUEMENT TRIÉS ISSUS DE CELLULES STROMALES MÉSENCHYMATEUSES (MSC) DÉRIVÉES DE MOELLE OSSEUSE EXPANSÉES EN CULTURE
Abstract: front page image
(EN)The invention provides, inter alia, populations of large mesenchymal stem cells (MSC)(as well as conditioned medium from these cells) with enhanced regenerative potential, as well as methods of culturing and using these populations, such as therapeutic methods of mediating tissue repair or enhancing homing and engraftment of hematopoietic stem cells. These large MSC populations can, in certain embodiments, be produced by biophysically sorting an MSC-containing population.
(FR)L'invention concerne, inter alia, des populations de grosses cellules souches mésenchymateuses (MSC) (et le milieu conditionné à partir de ces cellules) ayant un potentiel de régénération amélioré, ainsi que des procédés de culture et des méthodes d'utilisation de ces populations, telles que des méthodes thérapeutiques destinées à médier la réparation tissulaire ou à améliorer l'écotropisme et la prise de greffe des cellules souches hématopoïétiques. Ces grandes populations MSC peuvent, dans certains modes de réalisation, être produites par tri biophysique d'une population contenant des MSC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)