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1. (WO2015126048) ANTI-INFLAMMATORY COMPOSITION COMPRISING LORATADINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/126048    International Application No.:    PCT/KR2014/012422
Publication Date: 27.08.2015 International Filing Date: 16.12.2014
IPC:
A61K 31/445 (2006.01), A61K 31/44 (2006.01), A61P 29/00 (2006.01)
Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY [KR/KR]; Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 440-746 (KR)
Inventors: CHO, Jae Youl; (KR).
BAEK, Kwangsoo; (KR).
YANG, Woo Seok; (KR).
JEONG, Deok; (KR).
PARK, Jae Gwang; (KR)
Agent: LEE, Myoung-Jin; MJ International Patent Law Firm 6th floor, 28, Yeongdong-daero 85-gil Gangnam-gu Seoul 135-846 (KR)
Priority Data:
10-2014-0021207 24.02.2014 KR
10-2014-0179093 12.12.2014 KR
Title (EN) ANTI-INFLAMMATORY COMPOSITION COMPRISING LORATADINE
(FR) COMPOSITION ANTI-INFLAMMATOIRE COMPORTANT DE LA LORATADINE
(KO) 로라타딘을 포함하는 항염증용 조성물
Abstract: front page image
(EN)The present invention relates to an anti-inflammatory pharmaceutical composition, food composition and cosmetic composition comprising loratadine (ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate) as an active ingredient. The compositions of the present invention have an excellent anti-inflammatory effect by reducing the generation of NO and PGE2 which are inflammation-related factors. Also, the compositions show an effect of suppressing the secretion of mucus or digestive juices even when treated at a low concentration, and show no cytotoxicity even when treated at a high concentration, and therefore can be safely applied to pharmaceuticals, food and cosmetics. Accordingly, it is expected that the composition may be importantly applied as an anti-inflammatory agent.
(FR)La présente invention concerne une composition pharmaceutique anti-inflammatoire, une composition alimentaire et une composition cosmétique comportant de la loratadine (éthyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta [1,2-b]pyridine-11-ylidène)-1-pipéridinecarboxylate) comme principe actif. Les compositions de la présente invention ont un excellent effet anti-inflammatoires par réduction de la génération de NO et PGE2 qui sont des facteurs liés à l'inflammation. Les compositions présentent également un effet d'élimination de sécrétion de mucus ou de sucs digestifs même lors d'un traitement à faible concentration, ne présentent pas de cytotoxicité même lors d'un traitement à concentration élevée, et peuvent par conséquent être appliquées en toute sécurité sur des produits pharmaceutiques, alimentaires et cosmétiques. Par conséquent, il est attendu que la composition puisse être appliquée de manière importante comme agent anti-inflammatoire.
(KO)본 발명은 로라타딘(Loratadine, Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate)을 유효성분으로 함유하는 항염증용 약학적 조성물, 식품 조성물 및 화장료 조성물에 관한 것이다. 본 발명의 조성물은 염증관련 인자인 NO 및 PGE2의 생성을 감소시켜 우수한 소염 효과를 가진다. 또한 저농도로 처리하여도 점액 분비나 소화액 분비 억제에 있어서도 효과를 보이고, 고농도로 처리한 경우에도 세포독성을 보이지 않아서 의약품, 식품 및 화장료에 안전하게 적용할 수 있다. 따라서 항염증제로서 중요하게 응용될 수 있을 것으로 기대된다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)