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1. (WO2015125147) ANIONIC POLYPLEXES FOR USE IN THE DELIVERY OF NUCLEIC ACIDS

Pub. No.:    WO/2015/125147    International Application No.:    PCT/IL2015/050196
Publication Date: Fri Aug 28 01:59:59 CEST 2015 International Filing Date: Fri Feb 20 00:59:59 CET 2015
IPC: A61K 31/728
A61K 31/734
A61K 31/74
A61K 47/48
C12N 15/09
Applicants: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD
Inventors: COHEN, Smadar
KRYUKOV, Olga
RUVINOV, Emil
FORTI, Efrat
SHAMIR, Stav
Title: ANIONIC POLYPLEXES FOR USE IN THE DELIVERY OF NUCLEIC ACIDS
Abstract:
The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form of a nanoparticle or a microparticle and compositions comprising the anionic polyplex. The present invention further provides uses of the anionic polyplex such as delivery of the nucleic acid into cells and methods of treating a disease, disorder or condition selected from cancer or metabolic, neurodegenerative, cardiovascular, infectious or inflammatory diseases or disorders. The present invention also provides complexes comprising a divalent cation and a nucleic acid lacking an anionic polymer in the form of nanoparticles that is capable of forming a colloidal suspension, and methods for its production.