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|1. (WO2015125147) ANIONIC POLYPLEXES FOR USE IN THE DELIVERY OF NUCLEIC ACIDS|
|Applicants:||B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD
|Title:||ANIONIC POLYPLEXES FOR USE IN THE DELIVERY OF NUCLEIC ACIDS|
The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form of a nanoparticle or a microparticle and compositions comprising the anionic polyplex. The present invention further provides uses of the anionic polyplex such as delivery of the nucleic acid into cells and methods of treating a disease, disorder or condition selected from cancer or metabolic, neurodegenerative, cardiovascular, infectious or inflammatory diseases or disorders. The present invention also provides complexes comprising a divalent cation and a nucleic acid lacking an anionic polymer in the form of nanoparticles that is capable of forming a colloidal suspension, and methods for its production.