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1. (WO2015124737) METHODS, KITS, AND SYSTEMS FOR SCORING THE IMMUNE RESPONSE TO CANCER BY SIMULTANEOUS DETECTION OF CD3, CD8, CD20 AND FOXP3
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/124737    International Application No.:    PCT/EP2015/053643
Publication Date: 27.08.2015 International Filing Date: 20.02.2015
IPC:
G01N 33/574 (2006.01)
Applicants: VENTANA MEDICAL SYSTEMS, INC. [US/US]; 1910 Innovation Park Dr. Tucson, Arizona 85755 (US).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacher Strasse 124 CH-4070 Basel (CH) (CL only)
Inventors: SEBASTIAO, Noemi; (US).
DAY, William; (US).
OCHS, Robert; (US).
CHUKKA, Srinivas; (US).
MARTIN, Jim; (US).
BARNES, Michael; (US).
BREDNO, Joerg; (US).
CHEN, Ting; (US).
TUBBS, Alisa; (US).
NIE, Yao; (US)
Agent: GOEHRING, Frank; (DE)
Priority Data:
61/943,939 24.02.2014 US
Title (EN) METHODS, KITS, AND SYSTEMS FOR SCORING THE IMMUNE RESPONSE TO CANCER BY SIMULTANEOUS DETECTION OF CD3, CD8, CD20 AND FOXP3
(FR) PROCÉDÉS, NÉCESSAIRES ET SYSTÈMES POUR NOTER LA RÉPONSE IMMUNITAIRE À UN CANCER PAR DÉTECTION SIMULTANÉE DE CD3, CD8, CD20 ET FOXP3
Abstract: front page image
(EN)This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.
(FR)L'invention concerne des procédés, des nécessaires et des systèmes qui permettent de noter la réponse immunitaire à un cancer au moyen d'un examen de lymphocytes s'infiltrant dans les tissus (TIL). Des procédés pour noter la réponse immunitaire d'un cancer, utilisant des lymphocytes s'infiltrant dans les tissus, consistent à détecter CD3, CD8, CD20 et FoxP3 dans l'échantillon, et à noter la détection manuellement ou à noter les images numériques de la coloration à l'aide d'une analyse d'image et d'algorithmes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)