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1. (WO2015124576) 2-AMINO-3, 5, 5-TRIFLUORO-3, 4, 5, 6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/124576    International Application No.:    PCT/EP2015/053327
Publication Date: 27.08.2015 International Filing Date: 17.02.2015
IPC:
C07D 211/72 (2006.01), C07D 227/10 (2006.01), C07D 401/12 (2006.01), C07D 405/12 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), A61K 31/435 (2006.01)
Applicants: H. LUNDBECK A/S [DK/DK]; Ottiliavej 9 DK-2500 Valby (DK)
Inventors: JUHL, Karsten; (DK).
MARIGO, Mauro; (DK).
TAGMOSE, Lena; (DK).
JENSEN, Thomas; (DK)
Priority Data:
PA201400086 19.02.2014 DK
PA 2014 00349 01.07.2014 DK
Title (EN) 2-AMINO-3, 5, 5-TRIFLUORO-3, 4, 5, 6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE
(FR) 2-AMINO-3, 5, 5-TRIFLUORO-3, 4, 5, 6-TÉTRAHYDROPYRIDINES UTILISÉES EN TANT QU'INHIBITEURS DE BACE1 DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of Αβ deposits is beneficial such as Alzheimer's disease.
(FR)L'invention concerne de nouveaux inhibiteurs de l'enzyme BACE1. Différents aspects de l'invention concernent des compositions pharmaceutiques contenant lesdits composés, ainsi que les utilisations de ces composés dans le traitement de troubles dans lesquels la réduction de dépôts de bêta-amyloïdes est bénéfique, tels que la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)