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1. (WO2015124101) NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/124101    International Application No.:    PCT/CN2015/073121
Publication Date: 27.08.2015 International Filing Date: 15.02.2015
IPC:
C07D 231/56 (2006.01), C07D 491/048 (2006.01), C07D 495/04 (2006.01), C07D 261/20 (2006.01), A61K 31/416 (2006.01), A61K 31/4355 (2006.01), A61K 31/4365 (2006.01), A61K 31/519 (2006.01), A61K 31/422 (2006.01), A61K 31/4439 (2006.01), A61K 31/423 (2006.01), A61P 35/00 (2006.01), A61P 17/06 (2006.01), A61P 29/00 (2006.01), A61P 27/02 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zuchongzhi Road, Zhangjiang, Pudong Shanghai, 201203 (CN)
Inventors: DUAN, Wenhu; (CN).
DING, Jian; (CN).
LV, Yongcong; (CN).
XIE, Hua; (CN)
Agent: KINGSOUND & PARTNERS; 11/F, Block B, KingSound International Center, 116 Zizhuyuan Road, Haidian District Beijing 100097 (CN)
Priority Data:
201410062209.0 24.02.2014 CN
Title (EN) NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
(FR) COMPOSÉ NAPHTYLAMIDE, PROCÉDÉ DE PRÉPARATION ET UTILISATION DE CELUI-CI
(ZH) 萘酰胺类化合物、其制备方法和用途
Abstract: front page image
(EN)The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis.
(FR)La présente invention concerne un composé naphtylamide de la structure telle que représentée par la formule (I), ses sels médicinaux, ses promédicaments et ses hydrates ou ses solvates, et concerne également un procédé de préparation des composés, des compositions pharmaceutiques comprenant les composés et leurs utilisations en tant qu'inhibiteurs de la protéine tyrosine kinase, en particulier en tant qu'inhibiteurs VEGFR-2, dans la préparation de médicaments pour la prévention et le traitement de maladies liées à une angiogenèse anormale.
(ZH)本发明涉及如式(I)所示结构的萘酰胺类化合物、其药用盐、其前药及其水合物或溶剂合物,也涉及所述化合物的制备方法、包含所述化合物的药物组合物以及其作为蛋白酪氨酸激酶抑制剂,特别是作为VEGFR-2抑制剂,在制备预防和/或治疗与异常血管新生相关疾病的药物中的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)