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1. (WO2015123642) CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123642    International Application No.:    PCT/US2015/016057
Publication Date: 20.08.2015 International Filing Date: 16.02.2015
IPC:
C12N 15/85 (2006.01), C07K 14/705 (2006.01), C07K 19/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th St. Austin, TX 78701 (US)
Inventors: COOPER, Laurence, J.N.; (US).
KORNGOLD, Ana, Beatriz; (US).
RABINOVICH, Brian, A.; (US).
SINGH, Harjeet; (US).
OLIVARES, Simon; (US)
Agent: FINDLAY, Geoffrey, S.; (US)
Priority Data:
61/940,339 14.02.2014 US
Title (EN) CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
(FR) RÉCEPTEURS ANTIGÉNIQUES CHIMÉRIQUES ET PROCÉDÉ DE PRODUCTION
Abstract: front page image
(EN)Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
(FR)L'invention concerne des procédés de génération de récepteurs antigéniques chimériques (CAR). Selon certains modes de réalisation, le criblage de banques de CAR est effectué par la génération d'un vecteur codant pour les CAR à partir d'un attachement aléatoire de vecteurs de banques de vecteurs codant pour des domaines de liaison aux antigènes (p.ex., zones scFv), zones charnières et endodomaines. Selon certains modes de réalisation, les vecteurs contiennent un transposon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)