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1. (WO2015123595) CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123595    International Application No.:    PCT/US2015/015948
Publication Date: 20.08.2015 International Filing Date: 13.02.2015
IPC:
A61K 31/4025 (2006.01), C07D 407/12 (2006.01), A61P 33/06 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Twelfth Floor Oakland, California 94607-5200 (US)
Inventors: RENSLO, Adam R.; (US).
LAUTERWASSER, Erica M.W.; (DE).
FONTAINE, Shaun D.; (US).
SPANGLER, Benjamin B.; (US).
WELLS, James A.; (US)
Agent: NOMURA, Anson M.; (US)
Priority Data:
61/940,295 14.02.2014 US
Title (EN) CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
(FR) PEROXYDES CYCLIQUES UTILISÉS EN TANT QUE PROMÉDICAMENTS POUR L'ADMINISTRATION SÉLECTIVE D'AGENTS
Abstract: front page image
(EN)Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
(FR)L'invention concerne, inter alia, des compositions de promédicaments et des procédés d'utilisation de celles-ci pour le traitement et la détection d'une maladie. Plus spécifiquement, l'invention porte sur un composé de formule (I) comportant des cycles pipéridine et 1,2,4-trioxolane spiro-fusionnés, à savoir du 1,2,4-trioxa- 8-azaspiro[4.5] décane. L'invention concerne également une composition pharmaceutique contenant le composé et un support pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)