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Machine translation
1. (WO2015123496) IMMUNOTHERAPY OF CANCER THROUGH COMBINATION OF LOCAL AND SYSTEMIC IMMUNE STIMULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123496    International Application No.:    PCT/US2015/015767
Publication Date: 20.08.2015 International Filing Date: 13.02.2015
IPC:
A61K 39/00 (2006.01)
Applicants: IMMUNE DESIGN CORP. [US/US]; 1616 Eastlake Ave E. Suite 310 Seattle, WA 98102 (US)
Inventors: TER MEULEN, Jan, Henrik; (US).
PAYA CUENCA, Carlos, V.; (US)
Agent: BRUSCA, Eric M.; (US)
Priority Data:
61/940,109 14.02.2014 US
62/022,070 08.07.2014 US
62/101,335 08.01.2015 US
62/072,548 30.10.2014 US
61/985,787 29.04.2014 US
Title (EN) IMMUNOTHERAPY OF CANCER THROUGH COMBINATION OF LOCAL AND SYSTEMIC IMMUNE STIMULATION
(FR) IMMUNOTHÉRAPIE DU CANCER PAR COMBINAISON DE STIMULATION IMMUNITAIRE LOCALE ET SYSTÉMIQUE
Abstract: front page image
(EN)Provided herein are compositions and methods for immunotherapy of cancers, said methods combining systemic vaccination with a recombinant expression vector encoding a viral antigen and/or a cancer specific tumor antigen(s) to induce activated CD8 T-cells, with a local (e.g., intratumoral) immune stimulation using standard or modified application of a TLR agonist, to induce local inflammatory and innate immune responses which recruit T-cells to the tumor.
(FR)L'invention concerne des compositions et des procédés d'immunothérapie de cancers, lesdits procédés associant une vaccination systémique avec un vecteur d'expression recombinant codant pour un antigène viral et/ou un antigène tumoral spécifique du cancer (des antigènes tumoraux spécifiques du cancer) pour induire des cellules T CD8 activées, à une stimulation immunitaire locale (par exemple, intratumorale) à l'aide d'une application standard ou modifiée d'un agoniste de TLR, pour induire des réponses immunitaires locales innées et inflammatoires qui recrutent des cellules T au site de la tumeur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)