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1. (WO2015123423) METHODS FOR TREATING PATIENTS WITH HYPERCHOLESTEROLEMIA THAT IS NOT ADEQUATELY CONTROLLED BY MODERATE-DOSE STATIN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123423    International Application No.:    PCT/US2015/015633
Publication Date: 20.08.2015 International Filing Date: 12.02.2015
IPC:
A61K 39/00 (2006.01), A61K 39/395 (2006.01), A61P 9/10 (2006.01), C07K 16/40 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10592 (US).
SANOFI BIOTECHNOLOGY [FR/FR]; 54, rue La Boetie 75008 Paris (FR)
Inventors: PORDY, Robert, C.; (US).
SASIELA, William, J.; (US).
HARP, Joyce, B.; (US).
HANOTIN, Corinne; (FR).
BESSAC, Laurence; (FR)
Agent: SWANSON & BRATSCHUN, L.L.C; 8210 Southpark Terrace Littleton, CO 80120 (US)
Priority Data:
61/939,857 14.02.2014 US
62/000,162 19.05.2014 US
62/025,094 16.07.2014 US
62/052,227 18.09.2014 US
14306729.6 29.10.2014 EP
Title (EN) METHODS FOR TREATING PATIENTS WITH HYPERCHOLESTEROLEMIA THAT IS NOT ADEQUATELY CONTROLLED BY MODERATE-DOSE STATIN THERAPY
(FR) MÉTHODES DE TRAITEMENT DE PATIENTS ATTEINTS D'HYPERCHOLESTÉROLÉMIE NON CORRECTEMENT MAÎTRISÉE PAR UNE THÉRAPIE À LA STATINE À DOSE MODÉRÉE
Abstract: front page image
(EN)The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to a patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P. The methods of the present invention are useful for treating patients with hypercholesterolemia that is not adequately controlled by moderate-dose statin therapy.
(FR)L'invention concerne des méthodes de traitement de l'hypercholestérolémie. Les méthodes de l'invention consistent à administrer à un patient une composition pharmaceutique comprenant un inhibiteur de PCSK9. Dans certains modes de réalisation, l'inhibiteur de PCSK9 est un anticorps anti-PCSK9, tel que l'anticorps illustratif dénommé mAb316P dans la description. Les méthodes de l'invention sont utiles pour le traitement de patients atteints d'hypercholestérolémie non correctement maîtrisée par une thérapie à la statine à dose modérée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)