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1. (WO2015123398) ISOQUINOLINE DERIVATIVES AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123398    International Application No.:    PCT/US2015/015576
Publication Date: 20.08.2015 International Filing Date: 12.02.2015
IPC:
C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 403/04 (2006.01), A61K 31/4725 (2006.01), A61P 29/00 (2006.01), A61P 25/00 (2006.01)
Applicants: PURDUE PHARMA L.P. [US/US]; One Stamford Forum 201 Tresser Boulevard Stamford, CT (US)
Inventors: TAFESSE, Laykea; (US).
PARK, Jae, Hyun; (US)
Agent: YANG, Weiying; (US)
Priority Data:
61/939,082 12.02.2014 US
Title (EN) ISOQUINOLINE DERIVATIVES AND USE THEREOF
(FR) DÉRIVÉS D'ISOQUINOLINE ET LEUR UTILISATION
Abstract: front page image
(EN)The Invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof: wherein W1, W2, W3, J1, J2, A, R1, R2, R3, R4, R5, a, and b are defined as set forth in the specification. The Invention also provides uses of the compounds of any one of Formulae (I)- (VIII) and the pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof. Compounds of the Invention are useful for treating a disorder responsive to blockade of one or more sodium channels. In certain embodiments, Compounds of the Invention are useful for treating pain.
(FR)La présente invention concerne des composés de formule (I) et leurs sels, solvates, hydrates, N-oxydes, ou diastéréoisomères pharmaceutiquement acceptables : dans laquelle W1, W2, W3, J1, J2, A, R1, R2, R3, R4, R5, a et b sont tels que définis dans la description. L'invention concerne également des utilisations des composés selon l'une quelconque des formules (I) à (VIII) et leurs sels, solvates, hydrates, N-oxydes, ou diastéréoisomères pharmaceutiquement acceptables. Les composés de l'invention sont utiles pour le traitement d'un trouble sensible à un blocage d'un ou plusieurs canaux sodiques. Dans certains modes de réalisation, les composés de l'invention sont utiles pour le traitement de la douleur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)