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1. (WO2015123241) IMPROVED METHODS FOR THE TREATMENT OF VASCULARIZING CANCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/123241    International Application No.:    PCT/US2015/015320
Publication Date: 20.08.2015 International Filing Date: 11.02.2015
IPC:
A61K 39/00 (2006.01), A61K 39/395 (2006.01), C12P 21/08 (2006.01), C12N 5/07 (2010.01), G01N 33/569 (2006.01)
Applicants: CHI, Andrew, S. [US/US]; (US)
Inventors: CHI, Andrew, S.; (US)
Agent: AUERBACH, Jeffrey, I.; (US)
Priority Data:
61/939,804 14.02.2014 US
Title (EN) IMPROVED METHODS FOR THE TREATMENT OF VASCULARIZING CANCERS
(FR) PROCÉDÉS AMÉLIORÉS POUR LE TRAITEMENT DE CANCERS LIÉS À LA VASCULARISATION
Abstract: front page image
(EN)The invention concerns therapeutic compositions for the treatment of vascularizing cancers, especially, glioblastoma. In particular, the invention is directed to compositions that comprise a molecule having a binding ability that is specific for B7-H3 and a molecule having a binding ability that is specific for a cell-surface factor (or its receptor) that is involved in promoting tumor angiogenesis (especially VEGF or its receptor, VEGFR). The invention is additionally directed to the use of such compositions in the treatment of such cancers, and in particular, in the treatment of glioblastoma.
(FR)La présente invention concerne des compositions thérapeutiques pour le traitement de cancers liés à la vascularisation, en particulier, du glioblastome. Plus particulièrement, l'invention concerne des compositions comprenant une molécule possédant une capacité de liaison spécifique au B7-H3 et une molécule possédant une capacité de liaison spécifique à un facteur de surface cellulaire (ou son récepteur) qui est impliquée dans la promotion de l'angiogenèse tumorale (en particulier le VEGF ou son récepteur, le VEGFR). L'invention concerne en outre l'utilisation de ces compositions dans le traitement de tels cancers, et en particulier, dans le traitement du glioblastome.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)