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1. (WO2015122838) RAPIDLY DISSOLVABLE MICRONEEDLES WITH DRUG-IMPREGNATED TIPS

Pub. No.:    WO/2015/122838    International Application No.:    PCT/SG2014/000058
Publication Date: Fri Aug 21 01:59:59 CEST 2015 International Filing Date: Sat Feb 15 00:59:59 CET 2014
IPC: A61M 37/00
A61K 9/00
Applicants: LIM, Chee Yen
Inventors: LIM, Chee Yen
CHIA, Yong Wei
LEE, Wei Siong
Title: RAPIDLY DISSOLVABLE MICRONEEDLES WITH DRUG-IMPREGNATED TIPS
Abstract:
The present invention relates to rapidly dissolvable microneedles comprising drug-impregnated tips, the medical use thereof. In the preferred embodiment, the rapidly dissolvable microneedle patch (10) comprises a plurality of microneedles or tiny spikes (20) which are disposed on a back layer (30). The microneedles (20) have tapered geometry and have two parts on each microneedle (20), namely the drug tip (22) and the needle body (24). The drug tip (22), which occupies only a fraction of the volume of the apex of the microneedle, contains active pharmaceutical ingredients which are impregnated into the microneedle by centrifuging. In practice, only a portion of the microneedle (20) will be inserted into the skin. The penetration line (26) is an imaginary line dividing the inserted portion (32) of the microneedle (20) (inserted into the skin) and the non-inserted portion (34) of the microneedle (20) when the microneedle (20) is inserted into the skin. The inserted portion (32) extends from the apex (28) of the microneedle to the penetration line (26), and the non- inserted portion (34) extends from the penetration line (26) to the base (29) of the microneedle. In this way, the drug tip (22) which stays within the inserted portion (32) of the microneedle (20) is guaranteed to be fully delivered to the skin.