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1. (WO2015122570) MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO VIBRIO VULNIFICUS RTXA-1 PROTEIN AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/122570 International Application No.: PCT/KR2014/003659
Publication Date: 20.08.2015 International Filing Date: 25.04.2014
IPC:
C12N 5/20 (2006.01) ,C07K 16/12 (2006.01) ,A61K 39/40 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
16
Animal cells
18
Murine cells, e.g. mouse cells
20
one of the fusion partners being a B lymphocyte
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
40
bacterial
Applicants:
전북대학교 산학협력단 INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY [KR/KR]; 전라북도 전주시 덕진구 백제대로 567 567, Baekje-daero, Deokjin-gu Jeonju-si Jeollabuk-do 561-756, KR
Inventors:
정경민 CHUNG, Kyung Min; KR
이준행 RHEE, Joon Haeng; KR
우혜련 WOO, Hye Ryun; KR
이태희 LEE, Tae Hee; KR
Priority Data:
10-2014-001669313.02.2014KR
Title (EN) MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO VIBRIO VULNIFICUS RTXA-1 PROTEIN AND USE THEREOF
(FR) ANTICORPS MONOCONAL SE LIANT DE MANIÈRE SPÉCIFIQUE À LA PROTÉINE RTXA-1 DE VIBRIO VULNIFICUS ET UTILISATION DE CE DERNIER
(KO) 비브리오 패혈증균 알티엑스에이-1 단백질에 특이적으로 결합하는 단일클론 항체 및 이의 용도
Abstract:
(EN) The present invention relates to a monoclonal antibody specifically binding to Vibrio vulnificus RtxA-1 protein and a use thereof. More specifically, the monoclonal antibody has high sensitivity, specificity, and susceptibility through high-affinity specific binding capacity to Vibrio vulnificus, can be favorably used to prevent and treat diseases caused by Vibrio vulnificus and related infection, and has an excellent vaccine effect, and thus can be used as an agent for preventing and/or treating Vibrio vulnificus sepsis.
(FR) La présente invention concerne un anticorps monoclonal se liant de manière spécifique à la protéine RtxA-1 de Vibrio vulnificus et une utilisation de celui-ci. Plus spécifiquement, l'anticorps monoclonal présente des caractéristiques élevées de sensibilité, de spécificité et de réactivité via une capacité de liaison spécifique d’affinité élevée à Vibrio vulnificus, peut être favorablement utilisé dans le traitement prophylactique et thérapeutique des maladies provoquées par Vibrio vulnificus et d'infections apparentées, et présente un excellent effet de vaccin, et peut donc être utilisé en tant qu'agent dans le traitement prophylactique et/ou thérapeutique d'une septicémie à Vibrio vulnificus.
(KO) 본 발명은 비브리오 패혈증균 알티엑스에이-1(RtxA1)에 특이적으로 결합하는 단일클론항체 및 이의 용도에 관한 것으로, 보다 상세하게는 비브리오 패혈증균에 대한 고친화도의 특이적 결합능력으로 높은 감수성, 특이성 및 민감도를 가지며, 비브리오 패혈증균과 그에 관련된 감염에 의해서 유발되는 질병의 예방 및 치료에 유용하게 이용될 수 있으며, 우수한 백신효과를 가짐으로써 비브리오 패혈증 예방제 및/또는 치료제로 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)