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1. (WO2015122031) OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/122031    International Application No.:    PCT/JP2014/065880
Publication Date: 20.08.2015 International Filing Date: 16.06.2014
IPC:
C07D 211/42 (2006.01), A61K 31/452 (2006.01), A61P 11/00 (2006.01), A61P 11/08 (2006.01), A61P 29/00 (2006.01)
Applicants: LTT BIO-PHARMA CO.,LTD. [JP/JP]; 2-20, Kaigan 1-chome, Minato-ku, Tokyo 1050022 (JP)
Inventors: MIZUSHIMA, Toru; (JP)
Agent: KUSAMA, Osamu; (JP)
Priority Data:
2014-027539 17.02.2014 JP
Title (EN) OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT
(FR) FORME OPTIQUEMENT ACTIVE DU MÉPENZOLATE, ET AGENT DE SOULAGEMENT POUR BRONCHOPNEUMOPATHIE CHRONIQUE OBSTRUCTIVE QUI CONTIENT CELLE-CI EN TANT QUE PRINCIPE ACTIF
(JA) メペンゾラート光学活性体及びそれを有効成分とする慢性閉塞性肺疾患改善剤
Abstract: front page image
(EN)Provided are: an optically active form of mepenzolate bromide; and an ameliorating agent for chronic obstructive pulmonary disease, which contains the optically active form as an active ingredient and of which the activity relies on a bronchodilatory activity and an anti-inflammatory activity. (3R)- or (3S)-3-[(hydroxy)(diphenyl)acetoxy]-1,1-dimethyl- piperidinium bromide (also referred to as "(R)- or (S)-mepenzolate bromide"). An ameliorating agent for chronic obstructive pulmonary disease, which contains the (R)- or (S)-mepenzolate bromide as an active ingredient; or an ameliorating agent for chronic obstructive pulmonary disease as mentioned above, of which the route of administration is the administration through the respiratory tract or the administration through inhalation.
(FR)La présente invention concerne : une forme optiquement active de mépenzolate bromure ; et un agent de soulagement pour bronchopneumopathie chronique obstructive, qui contient la forme optiquement active en tant que principe actif et dont l'activité repose sur une activité bronchodilatatoire et une activité anti-inflammatoire. Bromure de (3R)- ou (3S)-3-[(hydroxy)(diphényl)acétoxy]-1,1-diméthyl-pipéridinium (également appelé « (R)- ou (S)-mépenzolate bromure »). La présente invention concerne un agent de soulagement pour bronchopneumopathie chronique obstructive, qui contient le (R)- ou (S)-mépenzolate bromure en tant que principe actif ; ou un agent de soulagement pour bronchopneumopathie chronique obstructive tel que mentionné ci-avant, dont la voie d'administration est l'administration par les voies respiratoires ou l'administration par inhalation.
(JA) メペンゾラート臭化物の光学活性体を提供し、またかかる光学活性体を有効成分として含有する気管支拡張作用及び抗炎症作用に基づく慢性閉塞性肺疾患改善剤を提供することであり、(3R)又は(3S)-3-[(ヒドロキシ)(ジフェニル)アセトキシ]-1,1-ジメチルピペリジニウム ブロマイド(以下、「(R)又は(S)-メペンゾラート臭化物」という)であり、係る(R)又は(S)-メペンゾラート臭化物を有効成分として含有する慢性閉塞性肺疾患改善剤であり、また、投与形態が、経気道投与又は吸入投与である慢性閉塞性肺疾患改善剤である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)