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1. (WO2015121812) NOVEL 3-(INDOL-3-YL)-PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

Pub. No.:    WO/2015/121812    International Application No.:    PCT/IB2015/051036
Publication Date: Fri Aug 21 01:59:59 CEST 2015 International Filing Date: Thu Feb 12 00:59:59 CET 2015
IPC: C07D 401/14
C07D 401/04
A61K 31/4439
A61P 35/00
A61P 25/00
A61P 31/12
A61P 3/04
C07D 471/04
A61K 31/437
Applicants: ITEOS THERAPEUTICS
Inventors: CROSIGNANI, Stefano
CAUWENBERGHS, Sandra
DRIESSENS, Gregory
DEROOSE, Frederik
Title: NOVEL 3-(INDOL-3-YL)-PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
Abstract:
The present invention relates to compound of Formula (I) or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.