WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2015121795) PHARMACEUTICAL COMBINATIONS COMPRISING A PI3K INHIBITOR FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/121795    International Application No.:    PCT/IB2015/050993
Publication Date: 20.08.2015 International Filing Date: 10.02.2015
IPC:
A61K 45/06 (2006.01), A61K 31/436 (2006.01), A61K 31/4439 (2006.01), A61K 31/5685 (2006.01), A61P 35/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
MASSACESI, Cristian [IT/FR]; (FR) (US only).
GERMA, Marie - Caroline [FR/FR]; (FR) (US only)
Inventors: MASSACESI, Cristian; (FR).
GERMA, Marie - Caroline; (FR)
Agent: RUDGE, Sewkian; (CH)
Priority Data:
14305179.5 11.02.2014 EP
Title (EN) PHARMACEUTICAL COMBINATIONS COMPRISING A PI3K INHIBITOR FOR THE TREATMENT OF CANCER
(FR) COMBINAISONS PHARMACEUTIQUES COMPRENANT UN INHIBITEUR DE PI3K PERMETTANT LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)A pharmaceutical combination comprising: (a) an alpha-isoform specific phosphatidylinositol-3- kinase inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1- dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or any pharmaceutically acceptable salt thereof, (b) an mTOR inhibitor and (c) exemestane or any pharmaceutically acceptable salt thereof, particularly for use in the treatment or prevention of a proliferative disease; uses of such a combination in the preparation of a medicament for the treatment or prevention of a proliferative disease; pharmaceutical compositions of the combination of said therapeutic agents and methods of treating a proliferative disease in a subject comprising administering to said subject a therapeutically effective amount of such a combination.
(FR)L'invention concerne une combinaison pharmaceutique comprenant : (a) un inhibiteur de phosphatidylinositol-3-kinase spécifique d'un alpha-isoforme, (S)-Pyrrolidine-1,2-acide dicarboxylique 2-acide amide 1-({4-méthyl-5-[2-(2,2,2-trifluoro-1,1-diméthyl-éthyl)-pyridin-4-yl]-thiazol-2-yl}-amide), ou tout sel pharmaceutiquement acceptable de ce dernier, (b) un inhibiteur de mTOR, et (c) l'exémestane ou tout sel pharmaceutiquement acceptable de ce dernier, en particulier pour l'utilisation dans le traitement ou la prévention d'une maladie proliférative ; des utilisations d'une telle combinaison dans la préparation d'un médicament permettant le traitement ou la prévention d'une maladie proliférative ; des compositions pharmaceutiques de la combinaison desdits agents thérapeutiques, et des méthodes de traitement d'une maladie proliférative chez un sujet, comprenant l'administration audit sujet d'une quantité thérapeutiquement efficace d'une telle combinaison.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)