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1. (WO2015121784) METHOD FOR DETECTION OF ANTI-RITUXIMAB ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/121784    International Application No.:    PCT/IB2015/050949
Publication Date: 20.08.2015 International Filing Date: 09.02.2015
IPC:
G01N 33/53 (2006.01), G01N 33/68 (2006.01), C12Q 1/00 (2006.01)
Applicants: DR. REDDY'S LABORATORIES LIMITED [IN/IN]; V. R. Srinivas, Ph.D. Intellectual Property Management Biologics development Center Survey Nos. 47, Bachupalli Qutubullapur, RR District – 500 090, Telangana, Hyderabad 500090 (IN)
Inventors: LELLA, Ravi Kumar; (IN).
MORAM, Narendra Babu; (IN).
KHAMBHAMPATY, Sridevi; (IN)
Priority Data:
644/CHE/2014 11.02.2014 IN
Title (EN) METHOD FOR DETECTION OF ANTI-RITUXIMAB ANTIBODIES
(FR) PROCÉDÉ DE DÉTECTION D'ANTICORPS ANTI-RITUXIMAB
Abstract: front page image
(EN)This invention is related to a method for detecting anti-rituximab antibodies in a RF positive plasma samples, wherein the method mitigated the interference of RF to a significant level using biotinylated F(ab)2 fragments of rituximab as detecting agent. The method also used a pre-treatment step with acidic buffer containing glycine, prior to subjecting the samples for detection of anti-rituximab antibodies.
(FR)La présente invention concerne un procédé qui permet de détecter des anticorps anti-rituximab dans des échantillons de plasma positif RF, le procédé atténuant l'interférence de RF à un niveau significatif à l'aide de fragments F(ab)2 biotinylés de rituximab comme agent de détection. Le procédé utilise également un étape de pré-traitement à l'aide d'un tampon acide contenant de la glycine, avant de soumettre les échantillons à la détection d'anticorps anti-rituximab.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)