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1. (WO2015121413) NEW ACTIVE PHARMACEUTICAL INGREDIENT COMBINATIONS WITH COMPOUNDS BASED ON TRI(HETERO)ARYL PYRAZOLES

Pub. No.:    WO/2015/121413    International Application No.:    PCT/EP2015/053091
Publication Date: Fri Aug 21 01:59:59 CEST 2015 International Filing Date: Sat Feb 14 00:59:59 CET 2015
IPC: A61K 31/437
A61K 31/519
A61P 31/12
Applicants: AICURIS GMBH & CO. KG
Inventors: URBAN, Andreas
WILDUM, Steffen
Title: NEW ACTIVE PHARMACEUTICAL INGREDIENT COMBINATIONS WITH COMPOUNDS BASED ON TRI(HETERO)ARYL PYRAZOLES
Abstract:
The present invention concerns new pharmaceutical active ingredient combinations from new compounds of non-nucleoside reverse transcriptase inhibitors with one or more additional and different antivirally active pharmaceutical ingredient(s). Furthermore, the present invention concerns the combined use of said pharmaceutical active ingredient combinations for the prevention and/or treatment of viral infections and of diseases caused by them. The combination partners in accordance with the invention preferably belong to different antiretroviral drug action classes and can be administered simultaneously in a single pharmaceutical composition or are provided separately in different pharmaceutical dosage forms that can be administered either simultaneously or sequentially. In particular, selected combination partners can be provided in proportions with synergistic antiviral effect. In particular, the present inventions concerns the combined use of said pharmaceutical active ingredient combinations for prevention and/or treatment of retroviral infections as well as of diseases caused by retroviruses, such as HIV infections, and of diseases such as AIDS, caused by them in humans and/or animals.