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1. (WO2015121348) PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES ENCAPSULATING A PLP-DEPENDENT ENZYME AND ITS COFACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/121348    International Application No.:    PCT/EP2015/052962
Publication Date: 20.08.2015 International Filing Date: 12.02.2015
IPC:
A61K 38/51 (2006.01), A61K 9/50 (2006.01), A61K 35/18 (2015.01), A61P 35/00 (2006.01)
Applicants: ERYTECH PHARMA [FR/FR]; 60 avenue Rockefeller F-69008 Lyon (FR)
Inventors: GODFRIN, Yann; (FR).
BOURGEAUX, Vanessa; (FR).
GAY, Fabien; (FR).
CORTESE, Thomas; (FR)
Agent: COLOMBET, Alain; (FR)
Priority Data:
1451100 12.02.2014 FR
Title (EN) PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES ENCAPSULATING A PLP-DEPENDENT ENZYME AND ITS COFACTOR
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT DES ÉRYTHROCYTES ENCAPSULANT UNE ENZYME DÉPENDANTE DU PLP ET SON COFACTEUR
Abstract: front page image
(EN)The invention relates to a pharmaceutical composition containing a PLP-dependent enzyme and optionally its cofactor, pyridoxal phosphate (PLP), and/or a phosphate or non-phosphate precursor of PLP, its use as a drug, its production method and a therapeutic treatment method related to it. The pharmaceutical composition comprises erythrocytes and a pharmaceutically acceptable vehicle, the erythrocytes encapsulating the PLP-dependent enzyme. The PLP-dependent enzyme may be methioninase, tyrosine phenol-lyase, tyrosine aminotransferase or cystathionine beta-synthase.
(FR)L'invention concerne une composition pharmaceutique contenant une enzyme dépendante du PLP et facultativement son cofacteur, le phosphate de pyridoxal (PLP), et/ou un précurseur phosphate ou non phosphate du PLP, son utilisation en tant que médicament, son procédé de production et un procédé de traitement thérapeutique associé. La composition pharmaceutique comprend des érythrocytes et un véhicule pharmaceutiquement acceptable, les érythrocytes encapsulant l'enzyme dépendante du PLP. L'enzyme dépendante du PLP peut être la méthioninase, la tyrosine phénol-lyase, tyrosine-aminotransférase ou la cystathionine bêta-synthase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)