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1. (WO2015121265) STABLE POLYMORPH FORM B OF TAPENTADOL HYDROCHLORIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/121265 International Application No.: PCT/EP2015/052785
Publication Date: 20.08.2015 International Filing Date: 10.02.2015
IPC:
C07C 215/54 (2006.01) ,A61K 31/135 (2006.01) ,A61P 13/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46
having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
48
with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
54
linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
Applicants: AZAD PHARMACEUTICAL INGREDIENTS AG[CH/CH]; Durachweg 15 CH-8200 Schaffhausen, CH
Inventors: BOCK, Dominique Anna; DE
MAIER, Thomas; DE
HAFERKAMP, Sven; DE
PORSTMANN, Frank; CH
Agent: MICHALSKI HÜTTERMANN & PARTNER PATENTANWÄLTE MBB; Dr. Uwe Albersmeyer Speditionstr. 21 40221 Düsseldorf, DE
Priority Data:
1402377.412.02.2014GB
Title (EN) STABLE POLYMORPH FORM B OF TAPENTADOL HYDROCHLORIDE
(FR) FORME POLYMORPHE B STABLE DU CHLORHYDRATE DE TAPENTADOL
Abstract:
(EN) The present invention relates to Tapentadol Hydrochloride in the polymorphic crystalline Form B, which is substantially free of polymorphic Form A as well as essentially free of low alkyl carboxylic acids or esters of such acids. Furthermore, the present invention provides a process to produce this polymorphic Form B substantially free of Form A and its preparation and use for pharmaceutical compositions. This process as well as the specific crystalline form is uncommon, improved and industrially advantageous. Furthermore, the invention relates to pharmaceutical compositions and uses thereof.
(FR) La présente invention concerne le chlorhydrate de tapentadol sous la forme polymorphe B cristalline, qui est sensiblement exempt de forme polymorphe A ainsi que sensiblement dépourvu d'acides alkyl carboxylique faibles ou d'esters de ces acides. En outre, la présente invention concerne un procédé pour produire cette forme polymorphe B sensiblement exempte de forme A et sa préparation et son utilisation pour des compositions pharmaceutiques. Ce procédé ainsi que la forme cristalline spécifique, n'est pas commun, est amélioré et industriellement avantageux. En outre, la présente invention concerne des compositions pharmaceutiques et leurs utilisations.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)