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1. (WO2015121166) USE OF SORTILIN AS BIOMARKER FOR AFFECTIVE/MOOD DISORDERS

Pub. No.:    WO/2015/121166    International Application No.:    PCT/EP2015/052506
Publication Date: Fri Aug 21 01:59:59 CEST 2015 International Filing Date: Sat Feb 07 00:59:59 CET 2015
IPC: G01N 33/68
C07K 14/705
Applicants: H. LUNDBECK A/S
Inventors: JEPSEN, Jesper, Lundhede
NYKJÆR, Anders
MORS, Niels, Peter, Ole
PETERSEN, Claus, Munck
ØSTERGAARD, Søren, Dinesen
GLERUP, Simon
Title: USE OF SORTILIN AS BIOMARKER FOR AFFECTIVE/MOOD DISORDERS
Abstract:
The present invention relates to the use of Sortilin as a biomarker. In particular, Sortilin is useful as a biomarker for affective disorders. In one aspect of the invention Sortilin may be used to aid the diagnosing and to monitor disease progression in bipolar disorder and unipolar depression by measuring Sortilin levels. The invention further provides methods for informing the choice of treatment of bipolar disorder and unipolar depression by determining the levels of Sortilin.