Search International and National Patent Collections

1. (WO2015120775) RECOMBINANT STRAIN PRODUCING L-AMINO ACIDS, CONSTRUCTING METHOD THEREFOR AND METHOD FOR PRODUCING L-AMINO ACIDS.

Pub. No.:    WO/2015/120775    International Application No.:    PCT/CN2015/072220
Publication Date: Fri Aug 21 01:59:59 CEST 2015 International Filing Date: Thu Feb 05 00:59:59 CET 2015
IPC: C12N 1/21
C12P 13/24
C12R 1/15
Applicants: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
中国科学院微生物研究所
Inventors: WEN, Tingyi
温廷益
SHANG, Xiuling
商秀玲
ZHANG, Yun
张芸
LIU, Shuwen
刘树文
LIANG, Yong
梁勇
ZHANG, Yu
张宇
Title: RECOMBINANT STRAIN PRODUCING L-AMINO ACIDS, CONSTRUCTING METHOD THEREFOR AND METHOD FOR PRODUCING L-AMINO ACIDS.
Abstract:
Provided is a recombinant strain producing L-amino acids, a constructing method therefor and a method for producing L-amino acids. Compared with the starting strains, the recombinant strain producing L-amino acids has decreased expression of 6-phosphoglucose isomerase Pgi and increased expression of 6-phosphogluconate dehydrogenase Zwf-OpcA. The starting strain can accumulate objective amino acids. Fermentation culturing of the recombinant strain can increase the yield of L-amino acids significantly. Also provided is a novel method for increasing the fermentation yield of L-amino acids, capable of being be used in bacterial fermentation of L-amino acids.