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Pub. No.:    WO/2015/120542    International Application No.:    PCT/CA2015/000084
Publication Date: 20.08.2015 International Filing Date: 12.02.2015
Chapter 2 Demand Filed:    11.12.2015    
C07K 19/00 (2006.01), C07K 14/025 (2006.01), C07K 14/16 (2006.01), C07K 14/435 (2006.01), C12N 1/21 (2006.01), C12N 15/62 (2006.01), C12N 15/63 (2006.01), C12N 15/85 (2006.01), C12N 15/87 (2006.01), C12N 5/10 (2006.01), C12P 21/02 (2006.01)
Applicants: SYMVIVO CORPORATION [CA/CA]; 102-4475 Wayburne Drive Burnaby, British Columbia V5G 4X4 (CA)
Inventors: GRAVES, Herbert Alexander; (CA).
FOX, Mark Andrew; (CA)
Agent: SECHLEY, Konrad; Gowling WLG (Canada) LLP 550 Burrard Street, Suite 2300, Bentall 5 Vancouver, British Columbia V6C 2B5 (CA)
Priority Data:
61/940,274 14.02.2014 US
61/940,258 14.02.2014 US
62/013,852 18.06.2014 US
Abstract: front page image
(EN)There are disclosed hybrid proteins comprising at least one signal sequence; at least one DNA binding domain; and at least one cell penetrating peptide (CPP) domain. In embodiments the CPP domain is a TAT domain, and the DNA binding domain is a HU domain. There is also disclosed the use of the hybrid proteins to introduce exogenous DNA into target cells, and methods for introducing exogenous DNA into target cells using the hybrid proteins.
(FR)Cette invention concerne des protéines hybrides comprenant au moins une séquence signal; au moins un domaine de liaison à l'ADN; et au moins un domaine de type peptide de pénétration cellulaire (CPP). Dans certains modes de réalisation, le domaine CPP est un domaine TAT, et le domaine de liaison à l'ADN est un domaine HU. L'utilisation des protéines hybrides selon l'invention pour introduire un ADN exogène dans des cellules cibles, et des procédés d'introduction d'un ADN exogène dans des cellules cibles à l'aide desdites protéines hybrides sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)