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1. (WO2015120476) INCREASING STORAGE OF VITAMIN A, VITAMIN D AND/OR LIPIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120476    International Application No.:    PCT/US2015/015272
Publication Date: 13.08.2015 International Filing Date: 10.02.2015
IPC:
A61K 9/51 (2006.01), A61P 35/00 (2006.01)
Applicants: SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; 10010 N. Torrey Pines Road La Jolla, CA 92037-1002 (US)
Inventors: EVANS, Ronald, M.; (US).
DOWNES, Michael; (US).
SHERMAN, Mara; (US).
DING, Ning; (US)
Agent: RYBAK, Sheree, Lynn; (US)
Priority Data:
61/938,056 10.02.2014 US
62/000,495 19.05.2014 US
Title (EN) INCREASING STORAGE OF VITAMIN A, VITAMIN D AND/OR LIPIDS
(FR) AUGMENTATION DU STOCKAGE DE VITAMINE A, DE VITAMINE D ET/OU DE LIPIDES
Abstract: front page image
(EN)The present disclosure provides compositions that include a nanoparticle and a compound that reduces the biological activity of one or more bromodomain and extra-terminal family member (BET) proteins (e.g., a bromodomain inhibitor), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell.
(FR)La présente invention concerne des compositions qui comprennent une nanoparticule et un composé qui réduit l'activité biologique d'une ou plusieurs protéines membres de la famille de bromodomaine et extra-terminale (BET) (par exemple, un inhibiteur de bromodomaine), et des procédés d'utilisation de tels composés pour augmenter la rétention ou le stockage de vitamine A, de vitamine D et/ou de lipides par une cellule, telle qu'une cellule épithéliale ou étoilée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)