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1. (WO2015120459) LIVE, ATTENUATED VACCINES AND METHODS OF MAKING AND USING
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/120459 International Application No.: PCT/US2015/015229
Publication Date: 13.08.2015 International Filing Date: 10.02.2015
IPC:
A61P 31/18 (2006.01) ,C12N 15/867 (2006.01) ,C12N 7/04 (2006.01)
Applicants: GUO, Jiantao[CN/US]; US
LI, Qingsheng[US/US]; US
NIU, Wei[CN/US]; US
LI, Yue[CN/US]; US
WANG, Nanxi[CN/US]; US
NUTECH VENTURES[US/US]; 1320 Q Street Lincoln, Nebraska 68508, US
Inventors: GUO, Jiantao; US
LI, Qingsheng; US
NIU, Wei; US
LI, Yue; US
WANG, Nanxi; US
Agent: PARSONS, M. Angela; US
Priority Data:
61/937,71210.02.2014US
Title (EN) LIVE, ATTENUATED VACCINES AND METHODS OF MAKING AND USING
(FR) VACCINS ATTÉNUÉS, VIVANTS ET PROCÉDÉS DE PRODUCTION ET D'UTILISATION
Abstract: front page image
(EN) A live, attenuated HIV vaccine is provided, and methods of making a live, attenuated HIV vaccine are provided. In one aspect, a live, · attenuated HIV vaccine is provided, where the genome of the HIV includes at least one first mutation in an essential region. Typically, the first mutation is a nonsense mutation. In some embodiments, the genome of the HIV further comprises at least one transgene in a non-essential region, the transgene encoding a suppressor tRNA and a corresponding aminoacyl-tRNA synthetase.
(FR) La présente invention porte sur un vaccin anti-VIH atténué, vivant, et sur des procédés de production d'un vaccin atténué du VIH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)