WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2015120457) STABILIZED ULTRA-RAPID-ACTING INSULIN FORMULATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120457    International Application No.:    PCT/US2015/015225
Publication Date: 13.08.2015 International Filing Date: 10.02.2015
IPC:
A61K 9/00 (2006.01), A61K 38/28 (2006.01), A61K 47/02 (2006.01), A61K 47/12 (2006.01), A61K 47/18 (2006.01)
Applicants: BIODEL INC. [US/US]; 100 Saw Mill Road Danbury, CT 06810 (US)
Inventors: WILSON, Bryan, R.; (US).
RAVULA, Pragati; (US).
LI, Ming; (US).
POHL, Roderike; (US).
HAUSER, Robert; (US)
Agent: PABST, Patrea, L.; (US)
Priority Data:
61/938,012 10.02.2014 US
Title (EN) STABILIZED ULTRA-RAPID-ACTING INSULIN FORMULATIONS
(FR) FORMULATIONS D’INSULINE À ACTION ULTRARAPIDE STABILISÉES
Abstract: front page image
(EN)Compositions and methods for enhancing the stability of rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid ("EDTA"), a dissolution/stabilization agent such as citric acid, a magnesium salt, a zinc compound and, optionally, additional excipients. New presentations include rapid acting concentrated insulin formulations and a way to enhance the absorption of commercially available rapid acting analog formulations while maintaining insulin stability.
(FR)La présente invention concerne des compositions et des procédés pour améliorer la stabilité de formulations d’insuline injectables à action rapide qui ont été développées pour injection sous-cutanée. Les formulations contiennent de l’insuline en combinaison avec un chélateur de zinc tel que l’acide éthylènediaminetétraacétique ("EDTA"), un agent de dissolution/stabilisation tel que l’acide citrique, un sel de magnésium, un composé de zinc et, facultativement, des excipients additionnels. Les nouvelles présentations comprennent des formulations d’insuline concentrées à action rapide et constituent un moyen pour augmenter l’absorption de formulations à action rapide analogues commercialisées tout en maintenant la stabilité de l’insuline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)