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Pub. No.:    WO/2015/120320    International Application No.:    PCT/US2015/014899
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
A61K 31/16 (2006.01), A01N 37/18 (2006.01), A01N 37/46 (2006.01), A61P 31/04 (2006.01)
Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; Somerset and George Streets New Brunswick, New Jersey 08903 (US).
EBRIGHT, Richard, H. [US/US]; (US).
EBRIGHT, Yon, W. [US/US]; (US).
MANDAL, Soma [IN/US]; (US).
WILDE, Richard [US/US]; (US).
LI, Shengjian [CN/US]; (US)
Inventors: EBRIGHT, Richard, H.; (US).
EBRIGHT, Yon, W.; (US).
MANDAL, Soma; (US).
WILDE, Richard; (US).
LI, Shengjian; (US)
Agent: HARRIS, Robert, J.; (US)
Priority Data:
61/936,710 06.02.2014 US
Abstract: front page image
(EN)The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment o prevention of M. tuberculosis infections in a mammal, is disclosed.
(FR)L'invention concerne des composés présentant une activité en tant qu'inhibiteurs d'ARN polymérase bactérienne et agents antibactériens, ainsi que des compositions comprenant les composés et des procédés pour leur utilisation. Spécifiquement, l'invention concerne des composés d'amide de phénylalanine et d'amide de tyrosine qui possèdent une activité inhibitrice dirigée contre une ARN polymérase de mycobacterium tuberculosis. L'invention concerne également l'utilisation de ces composés dans le traitement oo la prévention d'infections par M tuberculosis chez un mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)