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1. (WO2015120296) TARGETING P53 AND ITS DNA-BINDING DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120296    International Application No.:    PCT/US2015/014851
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
IPC:
A61K 38/00 (2006.01), C12N 15/12 (2006.01)
Applicants: UNIVERSTIY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive, Suite 301 Salt Lake City, UT 84108 (US)
Inventors: LIM, Carol; (US).
MATISSEK, Karina; (US).
MOSSALAM, Mohanad, A.; (US)
Agent: MARTY, Scott, D.; (US)
Priority Data:
61/944,384 25.02.2014 US
61/936,790 06.02.2014 US
Title (EN) TARGETING P53 AND ITS DNA-BINDING DOMAIN
(FR) CIBLAGE DE P53 ET DE SON DOMAINE DE LIAISON À L'ADN
Abstract: front page image
(EN)Disclosed are peptides comprising a full length p53 or a partial p53 and a mitochondrial targeting signal. Also disclosed are nucleic acids that encode peptides comprising a full length p53 or a partial p53 and a mitochondrial targeting signal. Further disclosed are methods of using the peptides and nucleic acids disclosed herein. For example, the peptides and nucleic acids can be used to treat hyperproliferative disorders.
(FR)L'invention concerne des peptides comprenant un p53 de longueur totale ou un p53 partiel et un signal de ciblage mitochondrial. L'invention concerne également des acides nucléiques qui codent des peptides comprenant un p53 de longueur totale ou un p53 partiel et un signal de ciblage mitochondrial. L'invention concerne en outre des procédés d'utilisation des peptides et des acides nucléiques de l'invention. Par exemple, les peptides et les acides nucléiques peuvent être utilisés pour traiter des troubles hyperprolifératifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)