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1. (WO2015120280) METHODS OF TREATING ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120280    International Application No.:    PCT/US2015/014829
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
IPC:
A61K 39/00 (2006.01), A61P 25/28 (2006.01), C07K 16/18 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (AE, AG, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, IR, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PA, PE, PG, PH, QA, RU, RW, SA, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only)
Inventors: GRAHAM, Robert; (US)
Agent: WAIS, Rebecca J.; (US)
Priority Data:
61/937,472 08.02.2014 US
61/971,499 27.03.2014 US
62/010,265 10.06.2014 US
62/082,013 19.11.2014 US
Title (EN) METHODS OF TREATING ALZHEIMER'S DISEASE
(FR) MÉTHODE DE TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.
(FR)L'invention concerne des méthodes de traitement de la Maladie d'Alzheimer (MA) chez des patients souffrant de MA légère à modérée, y compris des patients dont l'ApoE 4 est positif et des patients souffrant de MA légère. L'invention concerne également des méthodes de sélection ou d'identification de patients pour le traitement avec un anticorps anti-Abêta. Ces méthodes comprennent l'utilisation de biomarqueurs prédictifs et/ou pronostiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)