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1. (WO2015120257) USES OF GLI1 IN DETECTING TISSUE FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/120257 International Application No.: PCT/US2015/014796
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
IPC:
C12N 5/00 (2006.01) ,C12N 5/02 (2006.01) ,G01N 33/567 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.[US/US]; 75 Francis Street Boston, Massachusetts 02115, US
Inventors: HUMPHREYS, Benjamin D.; US
KRAMANN, Rafael; US
DIROCCO, Derek; US
Agent: RESNICK, David S.; US
Priority Data:
61/936,78306.02.2014US
62/011,25912.06.2014US
Title (EN) USES OF GLI1 IN DETECTING TISSUE FIBROSIS
(FR) UTILISATIONS DE GLI1 DANS LA DÉTECTION D'UNE FIBROSE TISSULAIRE
Abstract: front page image
(EN) Methods are provided herein for the use of Gli-1 as a specific marker for myofibroblast progenitor cells, thereby permitting the diagnosis of early stages of fibrosis prior to the onset of organ failure. Also provided herein are methods of isolating Gli-1+ cells for e.g., use in high-throughput screening of compounds for the treatment or prevention of fibrosis. In another aspect, provided herein are methods of treating or preventing fibrosis (e.g., kidney fibrosis) in a subject by administering a Gli inhibitor, particularly a Gli-2 inhibitor or a Gli-1/Gli-2 inhibitor.
(FR) L'invention concerne des procédés pour l'utilisation de Gli-1 en tant que marqueur spécifique des cellules progénitrices des myofibroblastes, permettant le diagnostic de stades précoces de la fibrose avant l'apparition de la défaillance d'un organe. L'invention concerne également des procédés d'isolement de cellules Gli-1+, par exemple pour les utiliser dans un criblage à haut débit de composés destinés au traitement ou à la prévention de la fibrose. Dans un autre aspect, l'invention concerne des procédés de traitement ou de prévention d'une fibrose (par exemple, une fibrose rénale) chez un sujet par l'administration d'un inhibiteur de Gli, en particulier un inhibiteur de Gli-2 ou un inhibiteur de Gli-1/Gli-2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)