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1. (WO2015120237) 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION

Pub. No.:    WO/2015/120237    International Application No.:    PCT/US2015/014762
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Sat Feb 07 00:59:59 CET 2015
IPC: A61K 31/7052
A61K 31/7072
C07H 19/04
Applicants: RIBOSCIENCE LLC
Inventors: SMITH, Mark
KLUMPP, Klaus G.
Title: 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION
Abstract:
The application discloses nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication. In particular, the application discloses the use of purine and pyrimidine nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication and pharmaceutical compositions containing such compounds.