WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2015120231) STABLE PEPTIDE FORMULATIONS AND METHODS FOR PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120231    International Application No.:    PCT/US2015/014756
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
IPC:
A61K 9/08 (2006.01), A61K 9/19 (2006.01), A61K 47/02 (2006.01), A61K 47/20 (2006.01), A61K 38/22 (2006.01), A61P 5/48 (2006.01)
Applicants: XERIS PHARMACEUTICALS, INC. [US/US]; 3208 Red River Suite 300 Austin, TX 78705 (US)
Inventors: PRESTRELSKI, Steven; (US).
DONOVAN, Martin; (US)
Agent: KRAWZSENEK, Michael, R.; (US)
Priority Data:
61/936,675 06.02.2014 US
Title (EN) STABLE PEPTIDE FORMULATIONS AND METHODS FOR PREPARATION
(FR) FORMULATIONS STABLES DE PEPTIDES ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract: front page image
(EN)Disclosed is a stable formulation for parenteral injection, as well as methods for its use and preparation, that includes a peptide or a salt thereof that has been previously dried from an aqueous composition comprising a partially volatile buffer, a volatile buffer, a strong acid, or a strong base, or any combination thereof, wherein the dried peptide or salt thereof has a first ionization profile that corresponds to the peptide's optimal stability and solubility, and an aprotic polar solvent, wherein the dried peptide or salt thereof is reconstituted into an aprotic polar solvent and has a second ionization profile in the aprotic polar solvent, wherein the first and second ionization profiles are substantially the same, such as within 1 pH unit of one another.
(FR)L'invention concerne une formulation stable pour injection parentérale, ainsi que ses procédés d'utilisation et de préparation. Ladite formulation comprend un peptide ou son sel, préalablement séché à partir d'une composition aqueuse comprenant un tampon partiellement volatile, un tampon volatile, un acide fort ou une base forte, ou une quelconque combinaison de ceux-ci, ledit peptide ou son sel séché présentant un premier profil d'ionisation correspondant à la stabilité et à la solubilité optimales du peptide, et un solvant polaire aprotique, ledit peptide ou son sel séché étant reconstitué dans un solvant polaire aprotique et présentant un second profil d'ionisation dans le solvant polaire aprotique, et les premier et second profils d'ionisation étant sensiblement identiques, par exemple ne différant pas de plus d'une unité de pH l'un de l'autre.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)