WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2015120225) ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120225    International Application No.:    PCT/US2015/014748
Publication Date: 13.08.2015 International Filing Date: 06.02.2015
IPC:
A61K 45/00 (2006.01), C12N 5/00 (2006.01), C12N 15/00 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, California 94305-2038 (US)
Inventors: COOKE, John P.; (US).
YAKUBOV, Eduard; (US)
Agent: SHERWOOD, Pamela J.; (US)
Priority Data:
61/937,923 10.02.2014 US
Title (EN) ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA
(FR) ACTIVATION DE L'IMMUNITÉ INNÉE POUR AMÉLIORER LA REPROGRAMMATION NUCLÉAIRE DE CELLULES SOMATIQUES AVEC UN ARNM
Abstract: front page image
(EN)The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.
(FR)La présente invention concerne la reprogrammation nucléaire de cellules somatiques avec un ARNm codant pour des facteurs de reprogrammation, qui est considérablement accélérée par l'activation de réponses immunitaires innées dans les cellules somatiques. L'invention porte en outre sur des procédés d'activation de l'immunité innée, comprenant l'activation de la Protéine Kinase PKR, de récepteurs de type toll, par exemple TLR3, etc. Dans certains modes de réalisation, l'ARNm concerne l'activateur de l'immunité innée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)