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1. (WO2015120206) MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120206    International Application No.:    PCT/US2015/014695
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
A61K 31/135 (2006.01), A61K 31/138 (2006.01), A61K 31/352 (2006.01), A61K 31/353 (2006.01), A61K 31/381 (2006.01), A61K 31/404 (2006.01), A61K 31/5375 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA [US/US]; USC Stevens 1150 South Olive Street, Suite 2300 Los Angeles, CA 90015 (US)
Inventors: SHIH, Jean, C.; (US).
HOFMAN, Florence, M.; (US).
CHEN, Thomas, C.; (US)
Agent: McCLURE, Lawrence, J.; (US)
Priority Data:
61/937,425 07.02.2014 US
Title (EN) MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER
(FR) INHIBITEURS DE LA MAO ET LEURS CONJUGUÉS UTILISABLES EN TANT QU'AGENTS THÉRAPEUTIQUES POUR LE TRAITEMENT DU CANCER DU CERVEAU
Abstract: front page image
(EN)A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148- clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
(FR)La présente invention concerne une composition pharmaceutique et une méthode de traitement du cancer du cerveau. Ladite méthode consiste à administrer à un patient qui en a besoin une quantité efficace d'un ou de plusieurs composés comprenant le moclobémide, la clorgyline, un complexe associant un inhibiteur de la monamine oxydase (imao) de type clorgyline et un colorant visible dans le proche infrarouge, et le complexe MHI 148-clorgyline, ainsi que leurs sels. Cette composition et cette méthode se montrent particulièrement efficaces pour ce qui est d'entraîner une réduction de la taille des glioblastomes résistants au témozolomide (TMZ).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)