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1. (WO2015120201) ABUSE-RESISTANT DRUG FORMULATIONS WITH BUILT-IN OVERDOSE PROTECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/120201    International Application No.:    PCT/US2015/014690
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
A61K 9/00 (2006.01)
Applicants: KASHIV PHARMA, LLC [US/US]; 995 US 202/206 Bridgewater, NJ 08807 (US)
Inventors: VAKA, Siva Ram Kiran; (US).
CHATTERJI, Ashish; (US).
DESAI, Dipen; (US).
PHUAPRADIT, Wantanee; (US).
SHAH, Navnit H.; (US).
THONGSUKMAK, Atsawin; (US).
MEGHPARA, Kanji; (US)
Agent: LEE, Sandra, S.; (US)
Priority Data:
61/935,971 05.02.2014 US
Title (EN) ABUSE-RESISTANT DRUG FORMULATIONS WITH BUILT-IN OVERDOSE PROTECTION
(FR) FORMULATIONS DE MÉDICAMENT RÉSISTANTES AUX ABUS AVEC PROTECTION INTÉGRÉE CONTRE LE SURDOSAGE
Abstract: front page image
(EN)Disclosed are solid oral pharmaceutical compositions that that are intended to provide protection against overdose and tampering, as well as abuse deterrence. The compositions contain a plurality of granules or multi-particulates. A first population of multi particulates contains an API or drug susceptible to abuse, a polymer matrix, and an outer coating that contains a cationic pH dependent polymer. These multi particulates also contain a plasticizer and a surfactant. A second population of multi particulates contains a viscosity building polymer and an alkaline buffering agent. Compositions may further include a disintegrant, and/or additional viscosity building polymers and/or alkaline buffering agents and/or ion exchange polymers. Also disclosed are the methods of making and using the compositions.
(FR)La présente invention concerne des compositions pharmaceutiques orales solides qui sont destinées à assurer la protection contre le surdosage et la violation, ainsi qu'à dissuader les abus. La composition contient une pluralité de granules ou de multi-particules. Une première population de multi-particules contient une substance active ou un médicament susceptible d'abus, une matrice de polymère, et un enrobage externe qui contient un polymère dépendant du pH cationique. Ces multi-particules contiennent en outre un plastifiant et un tensioactif. Une deuxième population de multi-particules contient un polymère adjuvant de viscosité et un agent tampon alcalin. Les compositions peuvent comprendre en outre un délitant, et/ou des polymères adjuvants de viscosité et/ou des agents tampons alcalins et/ou des polymères d'échange d'ions additionnels. L'invention concerne en outre les procédés de fabrication et d'utilisation des compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)