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1. (WO2015120180) CHIMERIC ANTIGEN RECEPTORS RECOGNIZING CANCER-SPECIFIC TN GLYCOPEPTIDE VARIANTS

Pub. No.:    WO/2015/120180    International Application No.:    PCT/US2015/014665
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Fri Feb 06 00:59:59 CET 2015
IPC: A61K 39/395
C07K 16/46
G01N 33/574
Applicants: THE UNIVERSITY OF CHICAGO
Inventors: SCHREIBER, Hans
IDEL, Christian
ENGELS, Boris
Title: CHIMERIC ANTIGEN RECEPTORS RECOGNIZING CANCER-SPECIFIC TN GLYCOPEPTIDE VARIANTS
Abstract:
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer- specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated T cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon- optimized coding regions and polynucleotides comprising coding regions that are not codon- optimized for expression in a particular host cell. Also disclosed are methods of making the encoded polypeptide and methods of using the polypeptide to treat, prevent or ameliorate the symptom of a disease such as cancer.