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1. (WO2015120171) NOVEL ASSAY TO DETECT HUMAN PERIOSTIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/120171 International Application No.: PCT/US2015/014652
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
C07K 16/18 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
MEDIMMUNE, LLC [US/US]; One Medimmune Way Gaithersburg, MD 20878, US
Inventors:
CHOWDHURY, Partha; US
VARKEY, Reena; US
LIANG, Meina; US
LEE, Yen-Wah; US
STREICHER, Katie; US
RANADE, Koustubh; US
GRANT, Ethan; US
GREENLEES, Lydia; US
YAO, Yihong; US
PARKER, Melissa; US
Agent:
MUELLER, Lisa; US
Priority Data:
61/936,96707.02.2014US
Title (EN) NOVEL ASSAY TO DETECT HUMAN PERIOSTIN
(FR) NOUVELLE ANALYSE PERMETTANT DE DÉTECTER LA PÉRIOSTINE HUMAINE
Abstract:
(EN) This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
(FR) La présente invention concerne une analyse robuste, sensible, et spécifique permettant de détecter et de mesurer des niveaux de périostine dans des échantillons obtenus chez des patients humains souffrant ou susceptibles de souffrir d'une maladie ou d'un trouble véhiculé par l'IL-13. L'invention concerne en outre de nouveaux anticorps monoclonaux dirigés contre la périostine, qui reconnaissent au moins les isoformes 1, 2, 3, 4, 7 et 8 de la périostine humaine, et des trousses d'analyse comprenant un ou plusieurs de ces anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)