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1. (WO2015120151) TOPICAL FORMULATION OF A SPIRO-OXINDOLE COMPOUND FOR TREATING PAIN ASSOCIATED WITH OSTEOARTHRITIS OF A JOINT

Pub. No.:    WO/2015/120151    International Application No.:    PCT/US2015/014627
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Fri Feb 06 00:59:59 CET 2015
IPC: A61K 9/00
A61K 47/10
A61K 9/06
A61K 31/407
A61P 19/02
A61K 31/167
Applicants: TEVA PHARMACEUTICALS INTERNATIONAL GMBH
Inventors: FETELL, Michael
MALAMUT, Richard
LAMSON, Michael, J.
SPIEGELSTEIN, Ofer
COHEN, Charles, Jay
GOLDBERG, Yigal, Paul
NAMDARI, Rostam
PRICE, Nicola, Anne
PROCTOR, Katie, Jane, Webster
Title: TOPICAL FORMULATION OF A SPIRO-OXINDOLE COMPOUND FOR TREATING PAIN ASSOCIATED WITH OSTEOARTHRITIS OF A JOINT
Abstract:
Methods of treating pain associated with osteoarthritis of a joint in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula (I) are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure.