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1. (WO2015120150) EXOSOMES AS A THERAPEUTIC FOR CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/120150 International Application No.: PCT/US2015/014623
Publication Date: 13.08.2015 International Filing Date: 05.02.2015
IPC:
A61K 9/48 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01)
Applicants: STC.UNM[US/US]; 801 University Blvd. Se Ste 101 Albuquerque, NM 87106, US
Inventors: TRUJILLO, Kristina; US
Agent: COLEMAN, Henry, D.; US
Priority Data:
61/936,09505.02.2014US
62/047,29708.09.2014US
Title (EN) EXOSOMES AS A THERAPEUTIC FOR CANCER
(FR) EXOSOMES EN TANT QU'AGENT THÉRAPEUTIQUE POUR LE CANCER
Abstract:
(EN) In one embodiment, the invention provides substantially purified exosomes which induce apoptosis in breast cancer cells and which are derived from a cultured medium of histologically normal breast tissue cells that are obtained from tumor-adjacent normal breast tissue. Related methods of treating breast cancer and pharmaceutical formulations are also provided.
(FR) Dans un mode de réalisation, l'invention concerne des exosomes sensiblement purifiés qui induisent une apoptose dans des cellules du cancer du sein et qui sont dérivés d'un milieu de culture de cellules de tissu mammaire histologiquement normales qui sont obtenues à partir de tissu mammaire normal adjacent à une tumeur. Elle concerne également des procédés associés de traitement du cancer du sein et des formulations pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)