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1. (WO2015120140) AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER

Pub. No.:    WO/2015/120140    International Application No.:    PCT/US2015/014601
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Fri Feb 06 00:59:59 CET 2015
IPC: C07D 493/08
A61K 31/352
A61P 35/00
A61P 3/00
A61P 31/00
A61P 9/00
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
UNIVERSITY OF HAWAII
Inventors: CHAIN, William J.
BEUTLER, John A.
FASH, David
FIGG, William D.
LI, Zhenwu
PEER, Cody John
RAMOS, Joe William
SULZMAIER, Florian J.
Title: AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER
Abstract:
Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).