WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2015119919) PHARMACEUTICAL COMPOSITION OF SELECTIVE HCV NS3/4A INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/119919    International Application No.:    PCT/US2015/014195
Publication Date: 13.08.2015 International Filing Date: 03.02.2015
IPC:
A61K 31/498 (2006.01), A61P 31/12 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
MAROTA, Melanie, J. [US/US]; (US) (US only).
MCKELVEY, Craig [US/US]; (US) (US only).
BIRRINGER, Nicholas [US/US]; (US) (US only).
KUIPER, Jesse [US/US]; (US) (US only).
HARMON, Paul, A. [US/US]; (US) (US only).
SOCIA, Adam, J. [US/US]; (US) (US only).
MARSAC, Patrick Jules [US/US]; (US) (US only).
CONWAY, Stephen, L. [US/US]; (US) (US only)
Inventors: MAROTA, Melanie, J.; (US).
MCKELVEY, Craig; (US).
BIRRINGER, Nicholas; (US).
KUIPER, Jesse; (US).
HARMON, Paul, A.; (US).
SOCIA, Adam, J.; (US).
MARSAC, Patrick Jules; (US).
CONWAY, Stephen, L.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/936,019 05.02.2014 US
Title (EN) PHARMACEUTICAL COMPOSITION OF SELECTIVE HCV NS3/4A INHIBITORS
(FR) COMPOSITION PHARMACEUTIQUE D'INHIBITEURS SÉLECTIFS DE LA NS3/4A DU HCV
Abstract: front page image
(EN)The present invention is directed to compositions comprising the HCV NS3/4A inhibitor, (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, or a pharmaceutically acceptable salt thererof, an oral absorption enhancing polymer, and, optionally, a surfactant. The present invention is also directed to solid dispersions and pharmaceutical compositions containing or made from these compositions, and the methods for making these solid dispersions and pharmaceutical compositions.
(FR)La présente invention concerne des compositions comprenant l'inhibiteur de la NS3/4A du VHC, ((1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-éthénylcyclopropyl}-14-méthoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tétradécahydro-8H-7,10-méthanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, ou un sel pharmaceutiquement acceptable de celui-ci, un polymère améliorant l'absorption par voie orale, et, facultativement, un agent tensioactif. La présente invention concerne également des dispersions solides et des compositions pharmaceutiques contenant ces compositions ou fabriquées à partir de celles-ci, ainsi que des procédés de fabrication de ces dispersions solides et de ces compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)